ACTIVE INCLUSION BODIES: THE UNEXPECTED JOURNEY

The demand for large-scale production of pure and functional proteins via cost-effective simple methods is highly emerging at present. In biotechnology, are synthesized in heterologous systems, since natural sources do not always allow satisfactory yields purity desired proteins. Heterologous systems focused to produce a high amount an expressed protein, often leading translation mechanism overload. As result, insoluble aggregates the protein called inclusion bodies (IBs) formed. Since beginning recombinant production, formation IBs has been seen as obstacle great afford made prevent their presence. On contrary, many independent studies recent decade challenged this wide-accepted opinion proved huge potential IBs. This review focuses on benefits tailored-made use self-immobilized catalysts used synthesis several industrially interesting products, well utilization different areas.